The present work carried out for emergence of antibiotic resistant bacterial strains and the gastro-intestinal helminthes are growing problems and are an important concern for patients, physicians, healthcare managers and policymakers as it results in poorer health and economic outcomes. Results of the antibacterial screening of aqueous and methanolic extracts of pericarp of the fruits of Sapindus trifoliatus revealed that more significant antibacterial activity possessed by aqueous extract than the methanolic extract against almost all the tested bacterial strains. Both the extracts showed paralysis of worms in a time nearer to that of Piperazine citrate, while showed death of worms in a less time compared to Piperazine citrate especially at higher concentration of 80 mg/ml. Antihelmintics and antibacterial agents derived from natural sources possess lesser side effects than synthetic drugs because of biological origin of natural source. This has led to an urgent global call for new antimicrobial drugs, particularly from natural resources.
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